Hyperosmotic applications of KCl induce vascular smooth muscle contraction which is independent of external Ca.
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منابع مشابه
Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle.
Smooth muscle contraction is activated by phosphorylation at Ser-19 of LC20 (the 20 kDa light chains of myosin II) by Ca2+/calmodulin-dependent MLCK (myosin light-chain kinase). Diphosphorylation of LC20 at Ser-19 and Thr-18 is observed in smooth muscle tissues and cultured cells in response to various contractile stimuli, and in pathological circumstances associated with hypercontractility. ML...
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Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to increased vascular contraction and arterial remo...
متن کاملCalcium and vascular smooth muscle contraction.
Radioactive calcium flux in rabbit aorta was studied to evaluate factors regulating the movement of calcium into and out of the cell. Calcium content was estimated both from (1) the amount of Ca present in the tissue and the specific activity of Ca in the bathing medium, and (2) determination of chemical calcium by atomic absorption spectrophotometry. Calcium efflux was followed by washing aort...
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Cao, W., Q. Chen, U. D. Sohn, N. Kim, M. T. Kirber, K. M. Harnett, J. Behar, and P. Biancani. Ca-induced contraction of cat esophageal circular smooth muscle cells. Am J Physiol Cell Physiol 280: C980–C992, 2001.— ACh-induced contraction of esophageal circular muscle (ESO) depends on Ca influx and activation of protein kinase Ce (PKCe). PKCe, however, is known to be Ca independent. To determine...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1983
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.33.246